Free A Spinal Exam 4 Practice

AIS is inherited in an X-linked recessive fashion because the androgen receptor gene that when mutated causes AIS sits on the X chromosome. In individuals with XY chromosomes, a single mutated copy disrupts androgen signaling, leading to insensitivity to androgens. Females, with two X chromosomes, are usually carriers because one normal copy can often compensate. Affected females are rare and typically require two mutated copies or unusual X-inactivation patterns. This explains why AIS largely affects males and why father-to-son transmission isn’t seen. An autosomal dominant pattern would imply roughly equal impact across sexes and different inheritance from fathers to sons, which doesn’t fit AIS.